Burns J R, Gauthier J F, Finlayson B
J Urol. 1984 Apr;131(4):708-11. doi: 10.1016/s0022-5347(17)50591-1.
Dissolution of uric acid calculi was studied in vitro. Calculated rate constants were then applied to an in vivo situation. The time required for complete dissolution of a uric acid calculus in a patient on oral alkali therapy can be estimated. Sodium bicarbonate, acetylcysteine, [tris(hydroxymethyl)aminomethane] and [tris(hydroxymethyl)aminomethane]-E were tested for relative effectiveness in dissolving uric acid calculi in vitro. In patients who require irrigation for dissolution of uric acid calculi [tris(hydroxymethyl)-aminomethane] is the preferred agent.
