Müller-Esch G, Valesky A, Weber U, Wood G
Klin Wochenschr. 1984 Jan 16;62(2):81-6. doi: 10.1007/BF01769667.
A 71-year-old woman with insulinoma was studied. Preoperatively, using the glucose controlled insulin infusion system (GCIIS) for glucose clamping at various blood glucose levels, autonomous insulin production was demonstrated and intravenous glucose needs for maintenance of normoglycaemia were evaluated. The results of a somatostatin suppression test, guided by the GCIIS, supported the postulation of a well differentiated beta cell adenoma with reduced storage capacity. These assumptions were later confirmed by histochemical and ultrastructural investigations. Hypoglycaemia during surgery was avoided by means of the GCIIS. Upon clamping of the plasma glucose at 90 mg/dl, 15.5 g dextrose had to be given until resection of the tumour. Immediately thereafter, a sharp rise in plasma glucose to 140 mg/dl together with a need for 4.1 U insulin showed that the insulinoma tissue had been removed completely.
对一名患有胰岛素瘤的71岁女性进行了研究。术前，使用葡萄糖控制胰岛素输注系统（GCIIS）在不同血糖水平下进行葡萄糖钳夹，证实了自主性胰岛素分泌，并评估了维持正常血糖所需的静脉葡萄糖量。在GCIIS指导下进行的生长抑素抑制试验结果支持了存在一个分化良好但储存能力降低的β细胞腺瘤的假设。这些假设后来通过组织化学和超微结构研究得到证实。通过GCIIS避免了手术期间的低血糖。将血浆葡萄糖钳夹在90mg/dl时，在肿瘤切除前必须给予15.5g葡萄糖。此后立即出现血浆葡萄糖急剧升至140mg/dl，同时需要4.1U胰岛素，这表明胰岛素瘤组织已被完全切除。
