通过高效液相色谱法（HPLC）和放射免疫分析法（RIA）联合分析血液和尿液中的δ9-四氢大麻酚代谢物来确认大麻使用情况。

Confirmation of cannabis use by the analysis of delta 9-tetrahydrocannabinol metabolites in blood and urine by combined HPLC and RIA.

作者信息

Law B, Mason P A, Moffat A C, King L J

出版信息

J Anal Toxicol. 1984 Jan-Feb;8(1):19-22. doi: 10.1093/jat/8.1.19.

DOI:10.1093/jat/8.1.19

Abstract

Cannabis use is confirmed through the analysis of blood and urine using combined high-performance liquid chromatography/radioimmunoassay to detect delta 9-THC-11-oic acid and its O-ester glucuronide (the major delta 9-THC metabolites). The method is sensitive and specific and will allow the complete analysis of at least six samples per day. It has been successfully applied to the analysis of samples submitted for forensic analysis and, in combination with a previously described radioimmunoassay, offers a useful approach to routine toxicological analysis of cannabinoid metabolites.

摘要

通过使用高效液相色谱法/放射免疫分析法联用检测δ9-四氢大麻酚-11-酸及其O-酯葡萄糖醛酸苷（主要的δ9-四氢大麻酚代谢物）来分析血液和尿液，从而确认大麻的使用情况。该方法灵敏且特异，每天至少能对六个样本进行完整分析。它已成功应用于提交法医分析的样本分析，并与先前描述的放射免疫分析法相结合，为大麻素代谢物的常规毒理学分析提供了一种有用的方法。

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