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通过高效液相色谱法(HPLC)和放射免疫分析法(RIA)联合分析血液和尿液中的δ9-四氢大麻酚代谢物来确认大麻使用情况。

Confirmation of cannabis use by the analysis of delta 9-tetrahydrocannabinol metabolites in blood and urine by combined HPLC and RIA.

作者信息

Law B, Mason P A, Moffat A C, King L J

出版信息

J Anal Toxicol. 1984 Jan-Feb;8(1):19-22. doi: 10.1093/jat/8.1.19.

DOI:10.1093/jat/8.1.19
PMID:6323852
Abstract

Cannabis use is confirmed through the analysis of blood and urine using combined high-performance liquid chromatography/radioimmunoassay to detect delta 9-THC-11-oic acid and its O-ester glucuronide (the major delta 9-THC metabolites). The method is sensitive and specific and will allow the complete analysis of at least six samples per day. It has been successfully applied to the analysis of samples submitted for forensic analysis and, in combination with a previously described radioimmunoassay, offers a useful approach to routine toxicological analysis of cannabinoid metabolites.

摘要

通过使用高效液相色谱法/放射免疫分析法联用检测δ9-四氢大麻酚-11-酸及其O-酯葡萄糖醛酸苷(主要的δ9-四氢大麻酚代谢物)来分析血液和尿液,从而确认大麻的使用情况。该方法灵敏且特异,每天至少能对六个样本进行完整分析。它已成功应用于提交法医分析的样本分析,并与先前描述的放射免疫分析法相结合,为大麻素代谢物的常规毒理学分析提供了一种有用的方法。

相似文献

1
Confirmation of cannabis use by the analysis of delta 9-tetrahydrocannabinol metabolites in blood and urine by combined HPLC and RIA.通过高效液相色谱法(HPLC)和放射免疫分析法(RIA)联合分析血液和尿液中的δ9-四氢大麻酚代谢物来确认大麻使用情况。
J Anal Toxicol. 1984 Jan-Feb;8(1):19-22. doi: 10.1093/jat/8.1.19.
2
A novel 125I radioimmunoassay for the analysis of delta 9-tetrahydrocannabinol and its metabolites in human body fluids.一种用于分析人体体液中Δ9 - 四氢大麻酚及其代谢物的新型125I放射免疫分析法。
J Anal Toxicol. 1984 Jan-Feb;8(1):14-8. doi: 10.1093/jat/8.1.14.
3
Forensic aspects of the metabolism and excretion of cannabinoids following oral ingestion of cannabis resin.口服大麻树脂后大麻素代谢与排泄的法医学研究
J Pharm Pharmacol. 1984 May;36(5):289-94. doi: 10.1111/j.2042-7158.1984.tb04376.x.
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Identification in human urine of delta 9-tetrahydrocannabinol-11-oic acid glucuronide: a tetrahydrocannabinol metabolite.
J Pharm Pharmacol. 1980 Jul;32(7):445-8. doi: 10.1111/j.2042-7158.1980.tb12966.x.
5
Confirmation of cannabis use. II. Determination of tetrahydrocannabinol metabolites in urine and plasma by HPLC with ECD.大麻使用的确认。二、采用高效液相色谱-电化学检测法测定尿液和血浆中的四氢大麻酚代谢物
J Anal Toxicol. 1989 Jan-Feb;13(1):22-4. doi: 10.1093/jat/13.1.22.
6
Combined high-performance liquid chromatography and radioimmunoassay method for the analysis of delta 9- tetrahydrocannabinol and its metabolites in plasma and urine.高效液相色谱法与放射免疫分析法联用测定血浆和尿液中Δ⁹-四氢大麻酚及其代谢物
NIDA Res Monogr. 1982;42:56-68.
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Combination of liquid chromatography with ultraviolet detection and gas chromatography with electron-capture detection for the determination of delta 9-tetrahydrocannabinol-11-oic acid in urine.液相色谱-紫外检测法与气相色谱-电子捕获检测法联用测定尿液中Δ⁹-四氢大麻酚-11-酸。
J Chromatogr. 1984 Mar 9;306:183-9. doi: 10.1016/s0378-4347(00)80881-6.
8
[Routine detection of the THC metabolite 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid in forensic practice].[法医实践中四氢大麻酚代谢物11-去甲-Δ⁹-四氢大麻酚-9-羧酸的常规检测]
Z Rechtsmed. 1983;90(2):105-8. doi: 10.1007/BF02092294.
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Profiles of delta 9-tetrahydrocannabinol metabolites in urine of marijuana users: preliminary observations by high performance liquid chromatography-radioimmunoassay.大麻使用者尿液中 Δ9-四氢大麻酚代谢物的概况:高效液相色谱-放射免疫分析法的初步观察
J Forensic Sci. 1986 Apr;31(2):695-706.
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Urinary excretion half-life of delta 1-tetrahydrocannabinol-7-oic acid in heavy marijuana users after smoking.重度大麻使用者吸食后δ1-四氢大麻酚-7-酸的尿排泄半衰期
J Anal Toxicol. 1989 Jul-Aug;13(4):218-23. doi: 10.1093/jat/13.4.218.

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