Nagy K, Koroknai L, Spät A
J Steroid Biochem. 1984 Mar;20(3):789-91. doi: 10.1016/0022-4731(84)90087-6.
We have studied the effects of human high density and low density lipoproteins on adrenocorticotropin (ACTH)-induced aldosterone production by isolated glomerulosa cells obtained from lipoprotein-deficient rats. ACTH increased basal aldosterone production, and the addition of either lipoprotein fraction further enhanced ACTH-induced aldosterone production. This increase could be shown at physiological lipoprotein-cholesterol concentrations. These data are compatible with a role of both high density and low density lipoproteins in supplying cholesterol to aldosterone-secreting glomerulosa cells.
我们研究了人高密度脂蛋白和低密度脂蛋白对从脂蛋白缺乏大鼠分离得到的球状带细胞中促肾上腺皮质激素（ACTH）诱导的醛固酮生成的影响。ACTH增加了基础醛固酮生成，并且添加任何一种脂蛋白组分都进一步增强了ACTH诱导的醛固酮生成。在生理脂蛋白胆固醇浓度下可显示出这种增加。这些数据与高密度脂蛋白和低密度脂蛋白在为分泌醛固酮的球状带细胞提供胆固醇方面的作用是一致的。
