Wilmes E, Wolf H, Haus M
Laryngol Rhinol Otol (Stuttg). 1983 Dec;62(12):586-9.
Epstein-Barr Virus is an important aetiological factor in the development of nasopharyngeal carcinoma (NPC). Serology suggested that besides NPC some other tumours located within the lymphoepithelial ring of the throat (Waldeyer's ring) might be associated with EBV. Nucleic-acid hybridizations were carried out to detect the presence of EBV-DNA in tumour biopsies derived from tonsillar carcinomas. We were able to demonstrate the presence of EBV-DNA in the tumour cells of two poorly differentiated carcinomas. We think that only a small fraction of tonsillar carcinomas is positive for EBV. The aetiologic relationship of EBV with tumours of Waldeyer's ring is discussed.
爱泼斯坦-巴尔病毒是鼻咽癌(NPC)发生发展的重要病因。血清学研究表明,除NPC外,位于咽喉淋巴上皮环(瓦尔代尔环)内的其他一些肿瘤可能与EBV有关。进行核酸杂交以检测扁桃体癌肿瘤活检组织中EBV-DNA的存在。我们能够在两例低分化癌的肿瘤细胞中证实EBV-DNA的存在。我们认为只有一小部分扁桃体癌EBV呈阳性。文中讨论了EBV与瓦尔代尔环肿瘤的病因学关系。