Faccini E, Uzumaki H, Govoni S, Missale C, Spano P F, Covelli V, Trabucchi M
Department of Pharmacology and Pharmacognosy, University of Milan, Milan, Italy Department of Pharmacology, University of Brescia, BresciaItaly.
Pain. 1984 Jan;18(1):25-31. doi: 10.1016/0304-3959(84)90123-4.
Met-enkephalin levels were measured in various spinal cord regions of rats chronically suffering from the inflammation of a single paw following a treatment with Freund's adjuvant. The results indicate that chronic localized pain induces a selective increase of met-enkephalin immunoreactive material (ME-IR) in the dorsal horn of the spinal cord segment which receives a direct projection from the inflamed paw. In order to gain information on the functional meaning of these data, either the plexus brachialis or the sciatic nerve were sectioned peripherally before inducing inflammation. Denervation prevented the increase of ME-IR concentration induced by the injection of Freund's adjuvant. Our observations suggest that chronic localized pain in a limb induces a change in ME-IR content which is selective for the spinal cord segment receiving a direct projection from the inflamed paw. This increase depends on an intact innervation.
在用弗氏佐剂治疗后，对长期患有单爪炎症的大鼠的各个脊髓区域的甲硫氨酸脑啡肽水平进行了测量。结果表明，慢性局部疼痛会导致在接受来自发炎爪子直接投射的脊髓节段的背角中，甲硫氨酸脑啡肽免疫反应性物质（ME-IR）选择性增加。为了获取有关这些数据功能意义的信息，在诱发炎症之前，对外周的臂丛神经或坐骨神经进行了切断。去神经支配阻止了弗氏佐剂注射所诱导的ME-IR浓度增加。我们的观察结果表明，肢体的慢性局部疼痛会导致ME-IR含量发生变化，这种变化对于接受来自发炎爪子直接投射的脊髓节段具有选择性。这种增加依赖于完整的神经支配。
