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抗抑郁治疗对中枢肾上腺素能系统的复杂作用：与临床疗效的可能关联。

Complex action of antidepressant treatment on central adrenergic system: possible relevance to clinical effects.

作者信息

Vetulani J

出版信息

Pharmacopsychiatry. 1984 Jan;17(1):16-21. doi: 10.1055/s-2007-1017401.

DOI:10.1055/s-2007-1017401
PMID:6324248
Abstract

Chronic antidepressant treatment with classical and atypical antidepressant drugs and ECT leads to complex changes in the central adrenergic system, consisting of upregulation of alpha 1 and downregulation of alpha 2 and beta adrenoceptors. These changes may lead to a specific facilitation of neurotransmission in structures employing alpha 1 adrenoceptors, involved in the control of mood and emotions.

摘要

使用经典和非典型抗抑郁药物以及电休克疗法进行慢性抗抑郁治疗会导致中枢肾上腺素能系统发生复杂变化，包括α1肾上腺素能受体上调以及α2和β肾上腺素能受体下调。这些变化可能导致在采用α1肾上腺素能受体的结构中神经传递的特定促进作用，而这些结构参与情绪和情感的控制。

相似文献

1
Complex action of antidepressant treatment on central adrenergic system: possible relevance to clinical effects.抗抑郁治疗对中枢肾上腺素能系统的复杂作用：与临床疗效的可能关联。
Pharmacopsychiatry. 1984 Jan;17(1):16-21. doi: 10.1055/s-2007-1017401.
2
Studies on the neurochemical basis of action of antidepressant drugs and electroconvulsive treatment.抗抑郁药物作用及电休克治疗的神经化学基础研究。
Pol J Pharmacol Pharm. 1984 Mar-Jun;36(2-3):101-15.
3
Effects of antidepressant treatments on 5-HT neurotransmission: electrophysiological and clinical studies.抗抑郁治疗对5-羟色胺神经传递的影响：电生理及临床研究
Adv Biochem Psychopharmacol. 1984;39:223-39.
4
[Antidepressant drugs and central monoaminergic receptors].[抗抑郁药物与中枢单胺能受体]
Yakubutsu Seishin Kodo. 1985 Dec;5(4):303-19.
5
Alpha up-beta down adrenergic regulation: a possible mechanism of action of antidepressant treatments.
Pol J Pharmacol Pharm. 1984 Mar-Jun;36(2-3):231-48.
6
Molecular and cellular mechanisms of antidepressant drugs.抗抑郁药物的分子和细胞机制
Depress Anxiety. 1996;4(4):153-9. doi: 10.1002/(SICI)1520-6394(1996)4:4<153::AID-DA1>3.0.CO;2-G.
7
[Pharmacology of central noradrenergic receptors (author's transl)].[中枢去甲肾上腺素能受体药理学（作者译）]
Encephale. 1982;8(2):177-92.
8
Receptors, adenylate cyclase, depression, and lithium.受体、腺苷酸环化酶、抑郁症与锂盐
Biol Psychiatry. 1981 Apr;16(4):333-50.
9
[A new concept of antidepressant drugs action: clinical and preclinical data].[抗抑郁药物作用的新概念：临床与临床前数据]
Psychiatr Pol. 1994 Jan-Feb;28(1):39-50.
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Does interaction between zinc and glutamate system play a significant role in the mechanism of antidepressant action?锌与谷氨酸系统之间的相互作用在抗抑郁作用机制中是否起重要作用？
Acta Pol Pharm. 2001 Jan-Feb;58(1):73-5.

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Repeated imipramine enhances sensitivity of the brain dopaminergic system related to exploratory behavior.
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Chronic treatment with the potential antidepressant drug rolipram: the effect on the behavioural responses to adrenergic and dopaminergic receptor agonists with some biochemical correlates.
J Neural Transm. 1985;64(3-4):211-26. doi: 10.1007/BF01256468.
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Biochemical and pharmacological effects of fluperlapine on noradrenaline and acetylcholine systems in some rodent, bovine and crustacean preparations.氟哌拉平对某些啮齿动物、牛和甲壳类动物制剂中去甲肾上腺素和乙酰胆碱系统的生化及药理作用。
Naunyn Schmiedebergs Arch Pharmacol. 1986 Apr;332(4):357-63. doi: 10.1007/BF00500087.
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Changes in the amount and distribution of neuronal alkaline and acid phosphatase after chronic exposure of cultures of cingulate cortex to antidepressant drugs.扣带回皮质培养物长期暴露于抗抑郁药物后神经元碱性磷酸酶和酸性磷酸酶的含量及分布变化。
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