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[体外暴露于γ射线和中子的小鼠组织中的自由基紊乱。放射化学产额]

[Free-radical disorders in the tissues of mice exposed to gamma irradiation and neutrons in vitro. The radiochemical yields].

作者信息

Svistunenko D A, Rikhireva G T, Pulatova M K, Ermakov V M

出版信息

Radiobiologiia. 1984 Jan-Feb;24(1):3-8.

PMID:6324272
Abstract

The ESR method was used to study free-radical disturbances in tissues of mouse liver and spleen exposed in vitro to gamma-radiation and fission neutrons. It was shown that both types of radiation induced damages to basic chemical components of the cell, namely, DNA, lipids, proteins, and water. The radiochemical yields of each radical registered were obtained and RBE of neutrons were evaluated with a reference to the formation in tissues of radicals of each type. Membrane lipids were shown to be markedly injured by neutrons.

摘要

采用电子自旋共振(ESR)方法研究了体外暴露于γ射线和裂变中子的小鼠肝脏和脾脏组织中的自由基紊乱情况。结果表明,两种类型的辐射均会对细胞的基本化学成分,即DNA、脂质、蛋白质和水造成损伤。获得了所记录的每种自由基的放射化学产额,并参照每种类型自由基在组织中的形成情况评估了中子的相对生物效应(RBE)。结果显示,中子对膜脂质有明显损伤。

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