Koliubaeva S N, Novoselova G S, Komar V E
Radiobiologiia. 1984 Jan-Feb;24(1):71-3.
During the first hours following nonuniform gamma-irradiation (the nonuniformity coefficient was 3:1 and 5:1 with a dose change along the axis directed cranio-caudally and caudo-cranially), endonuclease activity (pH 5.75) in the blood serum increased with the dose which was estimated with a reference to total utilization of the substrate. Supercoiled plasmid DNA served as the substrate. The transformation of a supercoiled form of plasmid DNA into an open circular form was the criterion of estimation of nuclease activity. It was shown that the increase in the nuclease activity correlated with the increase in the nonuniformity coefficient.
在非均匀γ射线照射后的最初几个小时内（不均匀系数分别为3:1和5:1，剂量沿头-尾和尾-头方向的轴变化），血清中的核酸内切酶活性（pH 5.75）随剂量增加，该剂量是根据底物的总利用率估算的。超螺旋质粒DNA用作底物。质粒DNA超螺旋形式转化为开环形式是核酸酶活性估算的标准。结果表明，核酸酶活性的增加与不均匀系数的增加相关。
