一些甾体自旋标记物的合成。

Synthesis of some steroid spin labels.

作者信息

Dodd J R, Mathew A E

出版信息

Steroids. 1983 Sep;42(3):241-7. doi: 10.1016/0039-128x(83)90036-3.

Abstract

An improved synthesis of spin-labeled cortisol, cortisone, and testosterone using N,N'-cyclohexylcarbodiimide (DCC) is reported. The spin labeled steroids are shown to result from the esterification at the most reactive C(21) and C(17) hydroxyl groups. A mild and high yield oxidation of cortisol spin label to cortisone spin label by chromium trioxide-pyridine is also discussed.

摘要

报道了一种使用N，N'-环己基碳二亚胺（DCC）改进的自旋标记皮质醇、可的松和睾酮的合成方法。自旋标记类固醇显示是由最具反应活性的C（21）和C（17）羟基酯化产生的。还讨论了通过三氧化铬-吡啶将皮质醇自旋标记温和且高产率地氧化为可的松自旋标记的方法。