Eklund S, Cassuto J, Jodal M, Lundgren O
Acta Physiol Scand. 1984 Feb;120(2):311-6. doi: 10.1111/j.1748-1716.1984.tb00139.x.
Intestinal fluid secretion was evoked in vivo in rats and cats by introducing dibutyrylcyclic adenosine 3,5-monophosphate (db-cAMP) or theophylline, a phosphodiesterase inhibitor, in the intestinal lumen. The intestines were denervated periarterially. It was demonstrated that three compounds of varying chemical structure and with different modes of action on nerves (tetrodotoxin, lidocaine, hexamethonium) decreased the secretory response 60-70%. It is concluded that the secretion induced by increasing the intracellular cAMP concentrations is in part evoked via the enteric nervous system.
通过在大鼠和猫的肠腔内注入二丁酰环磷腺苷3,5-单磷酸（db-cAMP）或磷酸二酯酶抑制剂茶碱，在体内诱发肠液分泌。对肠进行动脉周围去神经支配。结果表明，三种化学结构不同且对神经作用方式不同的化合物（河豚毒素、利多卡因、六甲铵）使分泌反应降低了60%-70%。得出的结论是，通过增加细胞内cAMP浓度诱导的分泌部分是通过肠神经系统诱发的。
