Kannangara D W, Gallagher K, Lefrock J L
Am J Med Sci. 1984 Mar-Apr;287(2):45-7. doi: 10.1097/00000441-198403000-00012.
A 54-year-old woman with recurrent adenocarcinoma of the uterus was treated with new third-generation cephalosporin, cefmenoxime, for a urinary tract infection. She received an alcohol-containing tylenol elixir while receiving the drug on two occasions. A disulfiram-like reaction was noticed each time. Such reactions have been described in patients receiving certain drugs such as 5-nitroimidazoles, nitrofurans, sulfonylureas and certain newer cephalosporins with a methyltetrazolethiol side chain. This is the first report of a disulfiram-like reaction with cefmenoxime. The mechanism, causes, and significance of disulfiram-like reactions are discussed.
一名54岁复发性子宫腺癌女性因尿路感染接受新型第三代头孢菌素头孢甲肟治疗。她在两次用药期间服用了含酒精的泰诺酏剂。每次都出现了双硫仑样反应。在接受某些药物（如5-硝基咪唑类、硝基呋喃类、磺酰脲类以及某些带有甲基四氮唑硫醇侧链的新型头孢菌素）治疗的患者中曾描述过此类反应。这是头孢甲肟引发双硫仑样反应的首例报告。文中讨论了双硫仑样反应的机制、成因及意义。
