Jacomini L C, Elghozi J L, Dagher G, Devynck M A, Meyer P
Arch Int Pharmacodyn Ther. 1984 Feb;267(2):310-8.
Ouabain was infused into the third cerebral ventricle of fully conscious, pentobarbital-anaesthetized or urethane-anaesthetized rats. Convulsive seizures occurred in the freely moving rats. The blood pressure of the pentobarbital-anaesthetized rats rose inconsistently. However, in those animals, anaesthetized with urethane, a consistent cardiovascular response was observed with an initial bradycardia, followed by a progressive increase in both the blood pressure and the heart rate. The hypertension was associated with a rise in the CSF potassium level. Tachyphylaxis to these responses was observed.
哇巴因被注入完全清醒、戊巴比妥麻醉或乌拉坦麻醉大鼠的第三脑室。自由活动的大鼠出现惊厥性癫痫发作。戊巴比妥麻醉大鼠的血压上升不稳定。然而，在那些用乌拉坦麻醉的动物中，观察到一致的心血管反应，先是心动过缓，随后血压和心率逐渐升高。高血压与脑脊液钾水平升高有关。观察到对这些反应的快速耐受性。
