Kamernitskiĭ A V, Reshetova I G, Mirsalikhova N M, Levi V G, Chernoburova E I
Biokhimiia. 1984 Feb;49(2):316-20.
The transformed steroids containing an additional cycle E (delta-lactone or 16.23-pyranone) or 23-carbethoxy side chain (1.10(-5) M) inhibit Na,K-ATPase from pig kidney medulla. The steroid structure has a noticeable effect on ATPase inhibiton varying from 9 to 35%. The data obtained suggest that the position, stereochemistry and the uneven distribution of polar substituents in the steroid molecule are essential for ATPase inhibition by steroid aglycons.
含有额外环E（δ-内酯或16,23-吡喃酮）或23-乙氧羰基侧链（1.10(-5)M）的转化甾体抑制猪肾髓质中的钠钾ATP酶。甾体结构对ATP酶抑制作用有显著影响，抑制率在9%至35%之间变化。所得数据表明，甾体分子中极性取代基的位置、立体化学和不均匀分布对于甾体苷元抑制ATP酶至关重要。
