在原代培养中，猪的睾丸间质细胞对促黄体素的处理速度比人绒毛膜促性腺激素快得多。
Lutropin is processed much more rapidly than human choriogonadotropin by porcine Leydig cells in primary culture.
作者信息
Salesse R, Genty N, Garnier J
出版信息
Biol Cell. 1983;49(2):187-90. doi: 10.1111/j.1768-322x.1984.tb00236.x.
Lutropin (LH) and human choriogonadotropin (hCG) share the same receptor and stimulate testosterone production in porcine Leydig cells in primary culture. Cells were pulsed with [125I]LH or [125I]hCG. During the chase, more than 80% of cell-bound LH consisted in internalized material which was degraded and excreted (half-time : 25 min) NH4Cl largely inhibited this degradation. On the contrary, hCG remained essentially bound to the cell surface and was not degraded by the cells with or without NH4Cl up to 160 min.
促黄体生成素（LH）和人绒毛膜促性腺激素（hCG）共用同一受体，并刺激原代培养的猪睾丸间质细胞产生睾酮。用[125I]LH或[125I]hCG对细胞进行脉冲处理。在追踪过程中，超过80%与细胞结合的LH是内化物质，这些物质会被降解并排出（半衰期：25分钟），NH4Cl在很大程度上抑制了这种降解。相反，hCG基本上仍结合在细胞表面，在有或没有NH4Cl的情况下，长达160分钟都不会被细胞降解。
Zotero 插件