Fibiger H C
Can J Neurol Sci. 1984 Feb;11(1 Suppl):105-7. doi: 10.1017/s0317167100046230.
Evidence from a variety of sources indicates that the mesolimbic-mesocortical dopamine projections may play an important role in some types of reward or reinforcement processes in animals. There is circumstantial evidence that this is also true in humans. Since a reduced ability to experience pleasure or reward (i.e. anhedonia) is a cardinal feature of clinical depression, and since the mesolimbic and mesocortical dopamine projections have been shown to degenerate in Parkinson's disease, it is suggested that damage to these reward-related systems may contribute directly to the high incidence of depression that has been reported in this disease.
来自各种来源的证据表明，中脑边缘 - 中脑皮质多巴胺投射可能在动物的某些类型的奖赏或强化过程中发挥重要作用。有间接证据表明在人类中也是如此。由于体验愉悦或奖赏的能力降低（即快感缺失）是临床抑郁症的主要特征，并且由于中脑边缘和中脑皮质多巴胺投射在帕金森病中已被证明会退化，因此有人提出，对这些与奖赏相关系统的损害可能直接导致了该疾病中所报道的高抑郁症发病率。
