小鼠经皮吸收[7,10-¹⁴C]苯并[a]芘和[7,12-¹⁴C]二甲基苯并[a]蒽的情况。
Percutaneous absorption of [7.10-14C]benzo[a]pyrene and [7,12-14C]dimethylbenz[a]anthracene in mice.
作者信息
Sanders C L, Skinner C, Gelman R A
出版信息
Environ Res. 1984 Apr;33(2):353-60. doi: 10.1016/0013-9351(84)90033-1.
PMID:6325143
Abstract
The percutaneous penetration, tissue distribution, and excretion of 14C-labeled benzo[a]pyrene (BaP) and dimethylbenz[a]anthracene (DMBA) were studied in mice. Both BaP and DMBA rapidly penetrated the skin and were excreted more in the feces than in the urine. The proportion of BaP or DMBA absorbed was less with increasing applied dose due to apparent saturation of the uptake process. Uptake from the dorsal skin of the nose was similar to uptake from the dorsal nuchal skin.
摘要
在小鼠中研究了14C标记的苯并[a]芘（BaP）和二甲基苯并[a]蒽（DMBA）的经皮渗透、组织分布及排泄情况。BaP和DMBA均能迅速穿透皮肤，且经粪便排泄的量多于尿液。由于摄取过程明显饱和，随着给药剂量增加，BaP或DMBA的吸收比例降低。从鼻背部皮肤的摄取与从项背部皮肤的摄取相似。
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