Mojaverian P, Swanson B N, Ferguson R K
Eur J Pharmacol. 1984 Feb 17;98(2):303-6. doi: 10.1016/0014-2999(84)90607-1.
Sprague-Dawley rats received oral doses of enalapril maleate (5 mg/kg), a potent, nonsulfhydryl, angiotensin converting enzyme inhibitor, or saline. Sixty min later, morphine sulfate, 5 mg/kg, or saline was injected subcutaneously. Response to a thermal stimulus was monitored before and up to 5 h ter morphine injection using the rat tail flick test. Serum ACE activity was greater than 90% inhibited by enalapril throughout the experiment. Enalapril did not exhibit analgesic activity nor did it potentiate morphine analgesia.
斯普拉格-道利大鼠口服马来酸依那普利（5毫克/千克），这是一种强效的、非巯基的血管紧张素转换酶抑制剂，或生理盐水。60分钟后，皮下注射5毫克/千克硫酸吗啡或生理盐水。使用大鼠甩尾试验监测吗啡注射前及注射后长达5小时对热刺激的反应。在整个实验过程中，依那普利对血清ACE活性的抑制率大于90%。依那普利未表现出镇痛活性，也未增强吗啡的镇痛作用。
