大鼠网织红细胞摄取铁的过程涉及两种机制。

Two mechanisms are involved in the process of iron-uptake by rat reticulocytes.

作者信息

van der Heul C, Veldman A, Kroos M J, van Eijk H G

出版信息

Int J Biochem. 1984;16(4):383-9. doi: 10.1016/0020-711x(84)90136-8.

Abstract

The iron uptake by red cell precursors has been studied in the presence of the carboxylic ionophore monensin, which achieves a concentration dependent inhibition of iron uptake, without influencing the transferrin uptake. It seems that two mechanisms are involved: Iron is released from endocytosed transferrin by acid vesicles. Iron is released from surface-receptor-bound transferrin at the plasma membrane, without internalization of the transferrin receptor complex.

摘要

在羧酸离子载体莫能菌素存在的情况下，对红细胞前体的铁摄取进行了研究。莫能菌素可实现对铁摄取的浓度依赖性抑制，而不影响转铁蛋白的摄取。似乎涉及两种机制：铁通过酸性囊泡从内吞的转铁蛋白中释放出来。铁在质膜处从与表面受体结合的转铁蛋白中释放出来，而转铁蛋白受体复合物不发生内化。