Sheetz M P, Wang W P, Kreutzer D L
Kroc Found Ser. 1984;16:87-94.
The membrane skeleton is a two-dimensional complex of actin, spectrinlike, and associated proteins which lies on the cytoplasmic face of most plasma membranes. Components of this complex are believed to control the lateral mobility of integral membrane proteins as well as influence cell shape and motility. In earlier studies we observed that the addition of polyphosphorylated inositol lipids could increased membrane skeleton dissociation. In preliminary studies of leukocyte function we have observed that increased chemotaxis with Trental addition is correlated with increased polyphosphoinositide levels. Consequently, we suggest that polyphosphoinositides contribute to, if not are requisite for, cellular mobility.
膜骨架是一种由肌动蛋白、血影蛋白样蛋白及相关蛋白组成的二维复合体，位于大多数质膜的细胞质面。据信，该复合体的成分可控制整合膜蛋白的侧向流动性，并影响细胞形状和运动性。在早期研究中，我们观察到添加多磷酸化肌醇脂可增加膜骨架解离。在白细胞功能的初步研究中，我们观察到添加曲克芦丁后趋化性增加与多磷酸肌醇水平升高相关。因此，我们认为多磷酸肌醇即使不是细胞运动所必需的，也对其有促进作用。
