白三烯（LTB4和LTD4）：对人淋巴细胞增殖和转化的体外作用。
Leukotrienes (LTB4 and LTD4): in vitro effects on human lymphocyte proliferation and transformation.
作者信息
Guttery J E, Tilden A, Herron D K, Gallagher P, Baker S R, Ades E W
出版信息
J Clin Lab Immunol. 1984 Mar;13(3):151-3.
PMID:6325698
Abstract
The effects of leukotrienes LTD4 and LTB4 on cell proliferation were assessed in a human in vitro lymphocyte transformation assay in the presence of optimal concentrations of PHA, Con A and PWM. Leukotriene D4 and LTB4 (10(-6) to 10(-11) M) did not alter the basal or mitogen-stimulated response. We therefore conclude that these two agents do not play a role in the modulation of human lymphocyte blastogenesis.
摘要
在存在最佳浓度的PHA、Con A和PWM的情况下，通过人体体外淋巴细胞转化试验评估白三烯LTD4和LTB4对细胞增殖的影响。白三烯D4和LTB4（10^(-6)至10^(-11) M）未改变基础或有丝分裂原刺激的反应。因此，我们得出结论，这两种物质在人类淋巴细胞增殖的调节中不起作用。
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