人类自然细胞毒性细胞活性：白三烯（LT）A4、B4和D4可增强其活性，但白三烯B4的立体异构体或羟二十碳四烯酸（HETES）则无此作用。
Human natural cytotoxic cell activity: enhancement by leukotrienes (LT) A4, B4 and D4, but not by stereoisomers of LTB4 or HETES.
作者信息
Rola-Pleszczynski M, Gagnon L, Rudzinska M, Borgeat P, Sirois P
出版信息
Prostaglandins Leukot Med. 1984 Jan;13(1):113-7. doi: 10.1016/0262-1746(84)90111-2.
PMID:6324237
Abstract
Natural cytotoxic activity of human lymphocytes was significantly enhanced by incubation with LTA4, LTB4 or LTD4. In contrast, stereoisomers of LTB4 as well as 5-HETE and 12-HETE were not active. These findings suggest that leukotrienes may play an important role in host defense mechanisms.
摘要
人淋巴细胞与白三烯A4（LTA4）、白三烯B4（LTB4）或白三烯D4（LTD4）孵育后，其天然细胞毒性活性显著增强。相比之下，LTB4的立体异构体以及5-羟基二十碳四烯酸（5-HETE）和12-羟基二十碳四烯酸（12-HETE）则无活性。这些发现表明，白三烯可能在宿主防御机制中发挥重要作用。
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