Lucchi L, Covelli V, Spano P F, Trabucchi M
Neurobehav Toxicol Teratol. 1984 Jan-Feb;6(1):19-21.
The present study investigated the effect of ethanol ingestion during pregnancy on central dopaminergic function in the nervous system of the offspring. Marked changes in striatum of both binding of 3H-spiperone and the concentrations of DOPAC were found in offspring particularly when an acute dose of ethanol was administered to pregnant dams on the fourth day of pregnancy, whereas changes in the binding of 3H-5HT in cortex were not seen. Interestingly, administration of ethanol from the fourth day to the end of gestation, or only on the 13th day, caused different effects or no effect, respectively. These data suggest that alterations of dopaminergic function may be markers of teratogenic effects of ethanol, and may be related to some of the clinical symptoms appearing in children affected by Fetal Alcohol Syndrome.
本研究调查了孕期摄入乙醇对后代神经系统中中枢多巴胺能功能的影响。在后代中发现纹状体中3H-司哌罗宁结合及3,4-二羟基苯乙酸（DOPAC）浓度有显著变化，尤其是在孕期第4天给怀孕母鼠急性注射乙醇时，而皮质中3H-5-羟色胺（5HT）结合未见变化。有趣的是，从孕期第4天至妊娠末期给予乙醇，或仅在第13天给予乙醇，分别产生了不同的影响或无影响。这些数据表明，多巴胺能功能的改变可能是乙醇致畸作用的标志物，并且可能与胎儿酒精综合征患儿出现的一些临床症状有关。
