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产前促肾上腺皮质激素和皮质酮:对雄性小鼠生殖的影响。

Prenatal ACTH and corticosterone: effects on reproduction in male mice.

作者信息

Politch J A, Herrenkohl L R

出版信息

Physiol Behav. 1984 Jan;32(1):135-7. doi: 10.1016/0031-9384(84)90085-4.

Abstract

Injections of ACTH or corticosterone into late pregnant mice from Days 14 to 21 did not alter testes weights or feminine copulatory behavior of male offspring in adulthood. However masculine copulatory behavior was significantly reduced. Because ACTH does not cross the placenta, alterations in sexual behavior of male offspring were probably mediated by maternal corticosteroid secretion.

摘要

在怀孕后期(第14天至21天)给小鼠注射促肾上腺皮质激素(ACTH)或皮质酮,并不会改变成年雄性后代的睾丸重量或雌性交配行为。然而,雄性交配行为显著减少。由于促肾上腺皮质激素不能穿过胎盘,雄性后代性行为的改变可能是由母体皮质类固醇分泌介导的。

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