母体应激会改变胎鼠和新生鼠大脑中的单胺代谢物。

Maternal stress alters monoamine metabolites in fetal and neonatal rat brain.

作者信息

Herrenkohl L R, Ribary U, Schlumpf M, Lichtensteiger W

机构信息

Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122.

出版信息

Experientia. 1988 May 15;44(5):457-9. doi: 10.1007/BF01940547.

DOI:10.1007/BF01940547

PMID:3371452

Abstract

Heat-restraint stress given rats during the last week of gestation significantly altered dopaminergic dihydroxyphenylacetic acid and homovanillic acid (DOPAC and HVA) and noradrenergic 3-methoxy-4-hydroxy-phenyl-ethylene glycol (MOPEG) forebrain-hypothalamic monoamine (MA) metabolites in female offspring. On gestational day 21, HVA and MOPEG were significantly higher and lower, and on postnatal day 1 all were higher. There were virtually no differences in brain MA concentrations in males. Thus MA metabolic concentrations differ in fetal-neonatal forebrain-hypothalamus as a function of sex differences and maternal stress.

摘要

在妊娠最后一周对大鼠施加热应激，会显著改变雌性后代中多巴胺能的二羟基苯乙酸和高香草酸（DOPAC和HVA）以及去甲肾上腺素能的3-甲氧基-4-羟基苯乙二醇（MOPEG）在前脑-下丘脑单胺（MA）代谢产物的水平。在妊娠第21天，HVA和MOPEG显著升高和降低，而在出生后第1天，所有指标均升高。雄性的脑MA浓度几乎没有差异。因此，胎儿-新生儿前脑-下丘脑的MA代谢浓度因性别差异和母体应激而有所不同。