Vincent J L
Resuscitation. 1984 Mar;11(3-4):175-82. doi: 10.1016/0300-9572(84)90015-7.
Increase in total cardiac output can improve oxygen delivery to the cells. Although inotropic drugs increase primarily myocardial contractility, they can adversely affect cardiac preload and afterload. Moreover, they can dangerously increase myocardial oxygen requirements. The combined use of vasodilating agents, with fluid challenge represents a challenging but more efficient treatment of acute circulatory failure.
心输出量增加可改善细胞的氧输送。虽然正性肌力药物主要增加心肌收缩力，但它们会对心脏前负荷和后负荷产生不利影响。此外，它们会危险地增加心肌需氧量。血管扩张剂与液体负荷联合使用，是治疗急性循环衰竭具有挑战性但更有效的方法。
