Carroll J E, Goodfriend T L
Science. 1984 Jun 1;224(4652):1009-11. doi: 10.1126/science.6326265.
Several polar androgens increased the binding of angiotensin and its stimulation of aldosteronogenesis in bovine adrenal glomerulosa cells. The effect was seen only if the steroids were applied to the cells and then washed away. This phenomenon and the technique for demonstrating it may have implications for studies of receptor modulation and for clinical states in which responsiveness to angiotensin is increased.
几种极性雄激素增加了血管紧张素与牛肾上腺球状带细胞的结合及其对醛固酮生成的刺激作用。只有当类固醇应用于细胞然后冲洗掉时才能观察到这种效应。这一现象及其证明技术可能对受体调节研究以及血管紧张素反应性增加的临床状态具有启示意义。
