氧化苯乙烯在一磷酸胸苷中形成磷酸二酯。
Formation of phosphodiesters in thymidine monophosphate by styrene oxide.
作者信息
Hemminki K, Suni R
出版信息
Toxicol Lett. 1984 Apr;21(1):59-63. doi: 10.1016/0378-4274(84)90224-8.
PMID:6326349
Abstract
Three products were isolated by high-performance liquid chromatography (HPLC) from the reaction between thymidine-5'-monophosphate (TMP) and styrene oxide in aqueous solution. None of the products was digested by alkaline phosphatase, but each was digested by vernom phosphodiesterase. The digestion products were identified by their mobility in HPLC and UV-spectra as phenylethylene glycol, thymidine, TMP, and hydroxyethylphenyl phosphoric acid, of which phenylethylene glycol and TMP were most abundant.
摘要
通过高效液相色谱法（HPLC）从胸苷-5'-单磷酸（TMP）与环氧苯乙烷在水溶液中的反应产物中分离出三种产物。这些产物均不能被碱性磷酸酶消化，但每种都能被蛇毒磷酸二酯酶消化。通过它们在HPLC中的迁移率和紫外光谱鉴定出消化产物为苯乙二醇、胸苷、TMP和羟乙基苯基磷酸，其中苯乙二醇和TMP含量最高。
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