Laditan A A
Afr J Med Med Sci. 1983 Sep-Dec;12(3-4):125-32.
Hormonal changes during the acute phase of protein-energy malnutrition (PEM) and at recovery have been examined in thirty-four severely malnourished subjects (twenty-four kwashiorkor and ten marasmus) all of whom were aged 3 years and below. It was observed that except for cortisol, the hormonal values were different between the marasmic and kwashiorkor children. Serum insulin levels were depressed and growth hormone (GH) elevated among the kwashiorkor children most especially among the kwashiorkor sub-groups II and III cases who had the greatest deficit in body weight. Although the GH values were also elevated in the marasmic patients, the levels were much lower than those for the kwashiorkor children. There was no statistically significant difference in the mean serum concentration of both cortisol and thyroxine among the different sub-groups of kwashiorkor and the marasmic subjects. The identical serum levels of cortisol in both the marasmic and kwashiorkor children may have been due to similar extent of exposure of infections. With improved dietary intake and some degree of anthropometric recovery, GH concentration fell steadily while insulin rose especially among the kwashiorkor cases. The reasons for these hormonal changes, their functions during the acute phase of PEM and at recovery are discussed.
对34名3岁及以下的严重营养不良儿童（24名夸休可尔症患儿和10名消瘦症患儿）在蛋白质 - 能量营养不良（PEM）急性期及恢复期间的激素变化进行了研究。观察发现，除皮质醇外，消瘦症和夸休可尔症患儿的激素值存在差异。夸休可尔症患儿的血清胰岛素水平降低，生长激素（GH）升高，尤其是在体重 deficit最大的夸休可尔症II组和III组患儿中。虽然消瘦症患者的GH值也升高，但水平远低于夸休可尔症患儿。夸休可尔症和消瘦症患儿的不同亚组之间，皮质醇和甲状腺素的平均血清浓度没有统计学上的显著差异。消瘦症和夸休可尔症患儿的皮质醇血清水平相同，可能是由于感染暴露程度相似。随着饮食摄入改善和一定程度的人体测量指标恢复，GH浓度稳步下降，而胰岛素上升，尤其是在夸休可尔症患儿中。本文讨论了这些激素变化的原因、它们在PEM急性期及恢复期间的作用。 （注：原文中“the greatest deficit in body weight”表述似乎不太完整准确，推测可能是“最大体重 deficit”，但不影响整体理解和翻译）
