Whitley N O, Fuks J Z, McCrea E S, Whitacre M, Masler J A, Whitley J E, Aisner J
AJR Am J Roentgenol. 1984 May;142(5):885-92. doi: 10.2214/ajr.142.5.885.
Computed tomography (CT) of the chest was performed as part of the initial and subsequent staging evaluations in 33 patients with small cell lung carcinoma. In 25 of the 33 patients, CT demonstrated findings not observed on standard radiography. Eleven of the 33 would have been staged higher using CT. Before treatment, CT revealed more mediastinal and nodal involvement than conventional films. After chemotherapy, CT demonstrated areas of residual or early recurrent disease in nine of 28 patients that were not apparent on chest films. Initially thickened pericardium in patients with limited disease and persistent bronchial narrowing after chemotherapy were demonstrated to be associated with early relapse in the chest and short survival. These initial data suggest that the CT scan, in addition to more accurately assessing the extent of disease, can provide a new risk classification for early chest relapse. Initial thickened pericardium in limited disease and continued bronchial narrowing after chemotherapy may allow patient selection for future treatment trials with radiation as an adjuvant to chemotherapy.
对33例小细胞肺癌患者进行胸部计算机断层扫描（CT）作为初始和后续分期评估的一部分。33例患者中有25例CT显示出标准X线摄影未观察到的结果。33例中有11例若使用CT进行分期会更高。治疗前，CT显示纵隔和淋巴结受累情况比传统胸片更多。化疗后，CT在28例患者中的9例显示出胸片上不明显的残留或早期复发疾病区域。疾病局限患者最初增厚的心包以及化疗后持续的支气管狭窄被证明与胸部早期复发和生存期短相关。这些初步数据表明，CT扫描除了能更准确地评估疾病范围外，还可为早期胸部复发提供新的风险分类。疾病局限患者最初增厚的心包以及化疗后持续的支气管狭窄可能有助于选择患者进行未来以放疗作为化疗辅助手段的治疗试验。
