Baughman R P, Fernandez M, Bosken C H, Mantil J, Hurtubise P
Am Rev Respir Dis. 1984 May;129(5):676-81. doi: 10.1164/arrd.1984.129.5.676.
Patients with active pulmonary sarcoidosis underwent bronchoalveolar lavage, gallium scan, and serum angiotensin-converting enzyme (ACE) level determination prior to treatment with corticosteroids. Pulmonary function was tested before and after therapy. Increase in vital capacity after treatment ranged from 40 to 1,030 ml; 12 of the 16 patients studied had an increase of more than 200 ml. There was a close correlation between the percentage uptake of gallium scan and the increase of the vital capacity after therapy (r = 0.95, p less than 0.01). There was no relationship between the percentage of lymphocytes obtained on lavage and the changes in vital capacity with therapy (r = 0.05). There was a positive correlation between the changes in vital capacity and the ratio of T4(+):T8(+)lymphocytes (r = 0.62, p less than 0.05) and number of T4 (+) lymphocytes (r = 0.92, p less than 0.01) in the bronchoalveolar fluid. There was a low correlation between the pretreatment ACE level and the change in vital capacity (r = 0.368, p greater than 0.05).
活动性肺结节病患者在接受皮质类固醇治疗前进行了支气管肺泡灌洗、镓扫描和血清血管紧张素转换酶（ACE）水平测定。在治疗前后对肺功能进行了测试。治疗后肺活量增加范围为40至1030毫升；16例研究患者中有12例增加超过200毫升。镓扫描摄取百分比与治疗后肺活量增加之间存在密切相关性（r = 0.95，p < 0.01）。灌洗获得的淋巴细胞百分比与治疗后肺活量变化之间无相关性（r = 0.05）。支气管肺泡液中肺活量变化与T4(+)：T8(+)淋巴细胞比例（r = 0.62，p < 0.05）和T4(+)淋巴细胞数量（r = 0.92，p < 0.01）呈正相关。治疗前ACE水平与肺活量变化之间相关性较低（r = 0.368，p > 0.05）。
