莫西沙星和1-甲基-5-硫代四氮唑在大鼠中导致低凝血酶原血症的产生。
Production of hypoprothrombinemia by moxalactam and 1-methyl-5-thiotetrazole in rats.
作者信息
Lipsky J J, Lewis J C, Novick W J
出版信息
Antimicrob Agents Chemother. 1984 Mar;25(3):380-1. doi: 10.1128/AAC.25.3.380.
Abstract
To determine whether the hypoprothrombinemia associated with antibiotics containing a 1-methyl-5-thiotetrazole (MTT) group is a result of the presence of the MTT group, rats were maintained on a vitamin K-deficient diet for 10 days and then received either intravenous moxalactam or cefotaxime or oral MTT for two additional days. MTT and moxalactam, which contains the MTT group, prolonged prothrombin time. Cefotaxime, which lacks the MTT group, had no effect.
摘要
为了确定与含有1-甲基-5-硫代四唑（MTT）基团的抗生素相关的低凝血酶原血症是否是MTT基团存在的结果，将大鼠维持在维生素K缺乏饮食10天，然后再额外两天接受静脉注射莫西沙星或头孢噻肟或口服MTT。MTT和含有MTT基团的莫西沙星延长了凝血酶原时间。缺乏MTT基团的头孢噻肟没有效果。
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