Nii S, Yamada M, Uno F
Biken J. 1983 Sep;26(3):127-31.
During serial passages of a non-giant cell-forming variant (-GCr) of the Miyama strain of type 1 herpes simplex virus, a new giant cell-forming variant named +GC(81) was isolated. CPE induced by this isolate was compared with that by -GCr and also by +GC(LPV), a derivative strain of the +GC variant of the Miyama strain. Rounding of single cells was observed after infection with -GCr. Remarkable syncytial formation was induced by +GC(LPV), the syncytia containing hundreds of nuclei, while small giant cells were formed by +GC(81). The reason for the appearance of +GC variants that differ in fusion capacity is discussed.
在单纯疱疹病毒1型宫胁株的非巨细胞形成变异体（-GCr）连续传代过程中，分离出一种名为+GC(81)的新的巨细胞形成变异体。将该分离株诱导的细胞病变效应与-GCr以及宫胁株+GC变异体的衍生株+GC(LPV)诱导的细胞病变效应进行了比较。感染-GCr后观察到单个细胞变圆。+GC(LPV)诱导形成显著的多核巨细胞，这些多核巨细胞含有数百个细胞核，而+GC(81)则形成小巨细胞。文中讨论了融合能力不同的+GC变异体出现的原因。
