鞘内注射阿片类药物后的僵住效应。

Cataleptic effects of opiates following intrathecal administration.

作者信息

Watkins L R, Frenk H, Miller J, Mayer D J

出版信息

Brain Res. 1984 May 7;299(1):43-9. doi: 10.1016/0006-8993(84)90786-8.

Abstract

Intrathecal (i.t.) administration of D-ala2-methionine-enkephalinamide (DALA) and methadone induces pronounced hindlimb catalepsy in rats. DALA is more potent than methadone in inducing this behavior and catalepsy induced by both compounds is partially blocked by prior treatment with naltrexone. Intrathecal morphine induces convulsive hindlimb activity at doses of 25, 100 and 400 micrograms. However, only the highest dose produces indications of cataleptic behavior. It is suggested that whereas the convulsive behavior induced by i.t. morphine is not mediated by specific opiate receptors, catalepsy induced by all 3 compounds is.

摘要

鞘内注射D-丙氨酸2-甲硫氨酸-脑啡肽酰胺（DALA）和美沙酮可在大鼠中诱发明显的后肢僵住症。DALA在诱发这种行为方面比美沙酮更有效，并且两种化合物诱发的僵住症都可被纳曲酮预处理部分阻断。鞘内注射吗啡在剂量为25、100和400微克时会诱发后肢惊厥活动。然而，只有最高剂量才会产生僵住行为的迹象。有人提出，鞘内注射吗啡诱发的惊厥行为不是由特定的阿片受体介导的，而所有这三种化合物诱发的僵住症则是由特定阿片受体介导的。