Frenk H, Watkins L R, Miller J, Mayer D J
Brain Res. 1984 May 7;299(1):51-9. doi: 10.1016/0006-8993(84)90787-x.
Cortical application of morphine (25, 100 and 400 micrograms) induced cortical spikes in a dose-related fashion and, at 400 micrograms, behavioral and electrographic seizures. These electrographic seizures were not opiate specific since this activity occurred undiminished in naltrexone-pretreated animals and was even potentiated in animals pretreated for 6 days with increasingly higher doses of systemic morphine. In contrast to the effects induced by morphine, the most consistent electrographic effect of cortically applied D-Ala2-methionine-enkephalin (DALA) and methadone was a depression of cortical EEG. These results support the hypothesis that the cortex and spinal cord together form the anatomical substrate of the documented nonspecific convulsive action of high systemically administered doses of morphine.
在皮层应用吗啡（25、100和400微克）以剂量相关的方式诱发皮层棘波，在400微克时，出现行为和脑电图癫痫发作。这些脑电图癫痫发作并非阿片类药物所特有，因为在纳曲酮预处理的动物中这种活动并未减弱，甚至在用越来越高剂量的全身吗啡预处理6天的动物中还得到增强。与吗啡诱导的效应相反，皮层应用D - 丙氨酸2 - 甲硫氨酸 - 脑啡肽（DALA）和美沙酮最一致的脑电图效应是皮层脑电图的抑制。这些结果支持这样一种假说，即皮层和脊髓共同构成了高剂量全身应用吗啡所记录到的非特异性惊厥作用的解剖学基础。
