Lazarov J
J Endocrinol. 1978 Mar;76(3):385-9. doi: 10.1677/joe.0.0760385.
After adrenalectomy, the absorption of [35S]thiamine in the small intestine of rats was significantly reduced. Injection of delta1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione (prednisolone) restored this absorption to some extent, but not to the value found in control (unoperated) rats. Treatment with 1% saline had no effect. Adrenalectomy also reduced the amount of [35S]thiamine that accumulated in the intestinal mucosa and liver compared with that found in controls, but treatment with prednisolone increased the retention of thiamine in these tissues. One per cent NaCl raised the retention of thiamine in the liver but not in the mucosa of the jejunum. The loss in body weight that occurred after adrenalectomy was not, however, corrected after treatment with either saline or steroid. In adrenalectomized rats, the concentrations of thiamine mono- and diphosphates in the intestinal mucosa and the liver were lower than in the control animals. The concentration of thiamine triphosphate was, however, higher in the intestinal mucosa after adrenalectomy, but remained unchanged in the liver. Treatment with prednisolone increased the concentrations of thiamine mono-, di- and triphosphates in both of these tissues in adrenalectomized rats, compared with unoperated control animals.
肾上腺切除术后，大鼠小肠对[35S]硫胺素的吸收显著降低。注射δ1,4-孕二烯-11β,17α,21-三醇-3,20-二酮（泼尼松龙）可在一定程度上恢复这种吸收，但未恢复到对照（未手术）大鼠的水平。用1%盐水处理无效。与对照组相比，肾上腺切除术还减少了肠黏膜和肝脏中积累的[35S]硫胺素的量，但用泼尼松龙处理增加了这些组织中硫胺素的保留量。1%氯化钠提高了肝脏中硫胺素的保留量，但未提高空肠黏膜中的保留量。然而，肾上腺切除术后出现的体重减轻在盐水或类固醇处理后并未得到纠正。在肾上腺切除的大鼠中，肠黏膜和肝脏中硫胺素单磷酸酯和二磷酸酯的浓度低于对照动物。然而，肾上腺切除术后肠黏膜中硫胺素三磷酸酯的浓度较高，但肝脏中该浓度保持不变。与未手术的对照动物相比，用泼尼松龙处理可增加肾上腺切除大鼠这两种组织中硫胺素单磷酸酯、二磷酸酯和三磷酸酯的浓度。
