百日咳毒素在离体仓鼠脂肪细胞中的直接作用。
Direct action of pertussis toxin in isolated hamster fat cells.
作者信息
Martínez-Olmedo M A, García-Sáinz J A
出版信息
Eur J Pharmacol. 1984 Mar 16;99(1):115-8. doi: 10.1016/0014-2999(84)90441-2.
PMID:6327335
Abstract
Incubation of pieces of adipose tissue in the presence of pertussis toxin (10-100 micrograms/ml) resulted in blockade in the isolated fat cells of the action of agents that inhibit adenylate cyclase through receptor-mediated GTP-dependent processes (alpha 2-adrenergic amines, prostaglandins, Ri-adenosine, nicotinic acid) and enhancement of the action of isoproterenol. There was a lag period of approximately 2 h for the action of the toxin.
摘要
在百日咳毒素（10 - 100微克/毫升）存在的情况下孵育脂肪组织切片，导致通过受体介导的GTP依赖性过程抑制腺苷酸环化酶的物质（α2 - 肾上腺素能胺、前列腺素、Ri - 腺苷、烟酸）在分离的脂肪细胞中的作用受阻，而异丙肾上腺素的作用增强。毒素的作用有大约2小时的延迟期。
Zotero 插件