Turner R W, Richardson T L, Miller J J
Exp Brain Res. 1984;54(3):567-70. doi: 10.1007/BF00235482.
The contribution of ephaptic interactions to potentiation of the hippocampal CA1 extracellular population spike during paired pulse or frequency stimulation of stratum radiatum (SR) inputs was investigated using the in vitro hippocampal slice preparation. Records of the transmembrane potential revealed a depolarizing wave with an amplitude and latency that varied directly with that of the extracellular population spike. Paired pulse or repetitive stimulation of SR resulted in a potentiation of the population spike amplitude and a corresponding increase in the amplitude of the TMP depolarizing wave. Action potentials generated during the stimulus train consistently arose from the peak of the depolarizing wave. It is proposed that ephaptic interactions contribute to potentiation of the extracellular population spike through recruitment of subthreshold neurons within the population during repetitive afferent stimulation.
利用体外海马脑片制备技术，研究了在对海马辐射层（SR）输入进行成对脉冲或频率刺激期间，电突触相互作用对海马CA1细胞外群体峰电位增强的贡献。跨膜电位记录显示出一个去极化波，其幅度和潜伏期与细胞外群体峰电位的幅度和潜伏期直接相关。对SR进行成对脉冲或重复刺激会导致群体峰电位幅度增强，以及跨膜电位去极化波幅度相应增加。刺激串期间产生的动作电位始终从去极化波的峰值处产生。有人提出，在重复传入刺激期间，电突触相互作用通过募集群体中的阈下神经元来促进细胞外群体峰电位的增强。
