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Effect of ellagic and caffeic acids on covalent binding of benzo[a]pyrene to epidermal DNA of mouse skin in organ culture.

作者信息

Shugart L, Kao J

出版信息

Int J Biochem. 1984;16(5):571-3. doi: 10.1016/0020-711x(84)90177-0.

DOI:10.1016/0020-711x(84)90177-0
PMID:6327419
Abstract

The covalent binding of the anti-diol epoxide of benzo[a]pyrene to cellular DNA of mouse skin in organ culture is affected by the presence of ellagic acid in the culture medium. At 10(-4) M, BaPDE /DNA formation is 40% less than that observed when no ellagic acid is present. Caffeic acid, a similar plant phenolic compound, demonstrates no inhibitory effect on BaPDE /formation. The plant phenolic acids do not drastically interfere with the metabolism of benzo[a]pyrene as shown by the BaP-metabolite profiles of the skin or of the culture medium.

摘要

相似文献

1
Effect of ellagic and caffeic acids on covalent binding of benzo[a]pyrene to epidermal DNA of mouse skin in organ culture.
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2
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