Shah R M, MacKay R A
J Embryol Exp Morphol. 1978 Feb;43:47-54.
A single intraperitoneal injection of 5-bromo-2-deoxyuridine (BUDR) between days 9 and 11 and a single intramuscular injection of 5-fluorouracil (FU) between days 8 and 11 of gestation were teratogenic in hamster. The malformation frequencies were related to the dose and time of BUDR and FU treatment but the pattern and types of malformations and their frequencies were different. BUDR showed lower embryotoxic effect than FU. Both drugs impaired general fetal growth. It is suggested that the differences between FU and BUDR may be related to the chemical nature and metabolism of the drug and their eventual effect on the species-specific target tissue.
在妊娠第9至11天腹腔内单次注射5-溴-2-脱氧尿苷（BUDR）以及在妊娠第8至11天肌肉内单次注射5-氟尿嘧啶（FU）对仓鼠具有致畸性。畸形频率与BUDR和FU的剂量及给药时间有关，但畸形的模式、类型及其频率有所不同。BUDR的胚胎毒性作用低于FU。两种药物均损害胎儿的整体生长。提示FU和BUDR之间的差异可能与药物的化学性质、代谢及其对物种特异性靶组织的最终作用有关。
