Kempin S, Sundaresan N, Shapiro W B, Arlin Z
J Neurosurg. 1984 Jun;60(6):1287-90. doi: 10.3171/jns.1984.60.6.1287.
Two patients with malignant brain tumors who developed acute nonlymphocytic leukemia after treatment with radiation and chemotherapy are described. Both patients survived more than 2 years after diagnosis of the brain tumor. Survival following the diagnosis of leukemia was short, and both patients died of hemorrhage secondary to thrombocytopenia. A review of the literature reveals that leukemia after combined-modality treatment of malignant brain tumors is rare. A prolonged survival period from diagnosis of the primary tumor, treatment with nitrosoureas and radiation, plus the development of a preleukemic myelodysplastic syndrome are all important features of therapy-related nonlymphocytic leukemia.
本文描述了两名患有恶性脑肿瘤的患者，他们在接受放疗和化疗后发生了急性非淋巴细胞白血病。两名患者在脑肿瘤诊断后均存活了2年以上。白血病诊断后的生存期较短，两名患者均死于血小板减少继发的出血。文献综述显示，恶性脑肿瘤联合治疗后发生白血病的情况很少见。从原发性肿瘤诊断开始的较长生存期、亚硝基脲和放疗治疗、以及白血病前期骨髓增生异常综合征的发生，都是治疗相关非淋巴细胞白血病的重要特征。
