5'-磷酸鸟苷增强5-氟-2'-脱氧尿苷的抗肿瘤活性
Potentiation of antitumor activity of 5-fluoro-2'-deoxyuridine by guanosine-5'-monophosphate.
作者信息
Iigo M, Hoshi A
出版信息
J Pharmacobiodyn. 1984 Jan;7(1):67-9. doi: 10.1248/bpb1978.7.67.
PMID:6327964
Abstract
The antitumor activity of 5-fluoro-2'-deoxyuridine (FUdR) against P388 leukemia was markedly enhanced by addition of guanosine-5'-monophosphate (GMP). With daily i.p. treatment for 5 d, the combination of FUdR at 100 mg/kg/d and GMP at 300 mg/kg/d showed the highest antitumor effect (more than 290% ILS), while maximum ILS of FUdR alone (100 mg/kg/d) was 94%.
摘要
通过添加5'-磷酸鸟苷（GMP），5-氟-2'-脱氧尿苷（FUdR）对P388白血病的抗肿瘤活性显著增强。每天腹腔注射治疗5天，100mg/kg/d的FUdR与300mg/kg/d的GMP联合使用显示出最高的抗肿瘤效果（超过290%的生命延长率），而单独使用FUdR（100mg/kg/d）的最大生命延长率为94%。
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