[Relation between the renin-angiotensin and kallikrein-kinin systems of the blood during physical loading of hypertension patients].

Blood angiotensin-converting enzyme, renin, kallikrein and prekallikrein ratios were investigated in 61 essentially hypertensive patients at rest and during rationed exercise. Biochemical findings were compared with major parameters of systemic hemodynamics measured under the same conditions. Grouping of patients on the basis of renin activity was mirrored in different levels of the angiotensin-converting enzyme and kallikrein: increased renin activity was accompanied by the activation of the said enzymes, and reduced activity, by their suppression. Rationed exercise did not produce noticeable kallikrein-kinin shifts in hypertensive patients, their renin-angiotensin response depending on the baseline. The markedness of hemodynamic change in response to exercise differed in patients with different humoral background.