皮质醇对肾上腺皮质膜中由1-24促肾上腺皮质激素刺激产生环磷酸腺苷的影响。
Effect of cortisol on cyclic AMP production stimulated by 1-24 ACTH in adrenal cortex membranes.
作者信息
Cook D B, Najafizadeh M, Solanki K U
出版信息
J Steroid Biochem. 1984 May;20(5):1113-5. doi: 10.1016/0022-4731(84)90352-2.
The effect of cortisol on cyclic AMP production by crude bovine adrenal cortex membrane preparations has been investigated. Results demonstrate that in the presence of cortisol, cyclic AMP production in response to 1-24 ACTH was enhanced up to a concentration of about 74 microM cortisol. At higher concentrations the effect was reversed. Cortisol had no effect on cyclic AMP production in the absence of 1-24 ACTH, and cyclic AMP production was completely inhibited when 5 mM EDTA was added to the incubation tubes with the cortisol.
已对皮质醇对粗制牛肾上腺皮质膜制剂产生环磷酸腺苷（cAMP）的影响进行了研究。结果表明，在存在皮质醇的情况下，对于1-24促肾上腺皮质激素（ACTH），直至皮质醇浓度约为74微摩尔时，cAMP的产生都会增强。在更高浓度时，这种作用会逆转。在不存在1-24 ACTH的情况下，皮质醇对cAMP的产生没有影响，并且当在含有皮质醇的孵育管中加入5毫摩尔乙二胺四乙酸（EDTA）时，cAMP的产生会被完全抑制。
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