El Ayat A A, Mahesh V B
J Steroid Biochem. 1984 May;20(5):1141-5. doi: 10.1016/0022-4731(84)90357-1.
Anterior pituitary gland and hypothalamic 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) activity was measured in the immature castrated estradiol primed rat to determine if differences in enzyme activity could explain the progesterone induced reduction of bound estradiol nuclear receptors of the anterior pituitary gland but not the hypothalamus. Higher levels of 17 beta-HSD activity were found in the anterior pituitary gland as compared to the hypothalamus. The enzyme activity in the anterior pituitary gland was stimulated by progesterone administered either in combination with estradiol for 4 days or as a single injection following 4 days of estradiol priming. No progesterone effects were found on hypothalamic 17 beta-HSD. Under the experimental conditions used, progesterone administration did not alter uterine 17 beta-HSD. An increase in anterior pituitary gland and uterine 17 beta-HSD was also induced by estrogen administration.
在未成熟去势且用雌二醇预处理的大鼠中，检测垂体前叶和下丘脑的17β-羟基类固醇脱氢酶（17β-HSD）活性，以确定酶活性的差异是否可以解释孕酮诱导的垂体前叶而非下丘脑结合雌二醇核受体减少的现象。与下丘脑相比，垂体前叶中发现了更高水平的17β-HSD活性。当孕酮与雌二醇联合给药4天或在雌二醇预处理4天后单次注射时，垂体前叶的酶活性受到刺激。未发现孕酮对下丘脑17β-HSD有影响。在所使用的实验条件下，给予孕酮不会改变子宫17β-HSD。雌激素给药也可诱导垂体前叶和子宫17β-HSD增加。
