Gibbs D M, Vale W, Rivier J, Yen S S
Life Sci. 1984 Jun 4;34(23):2245-9. doi: 10.1016/0024-3205(84)90212-1.
The effects of CRF(41), oxytocin (OT), and arginine vasopressin (AVP) on ACTH secretion were studied alone and in combination in an in vitro system of superfused rat hemipituitaries. CRF(41) (10(-9)M) and AVP (10(-8)M) alone produced a significant increase in ACTH secretion while OT (10(-8)M) alone had no effect. However the same concentration of OT markedly potentiated the ACTH response to CRF(41) while having no effect on the ACTH response to AVP. The data support a physiologic role for OT in the regulation of ACTH secretion.
在大鼠半垂体体外灌流系统中，单独及联合研究了促肾上腺皮质激素释放因子（CRF(41)）、催产素（OT）和精氨酸加压素（AVP）对促肾上腺皮质激素（ACTH）分泌的影响。单独使用CRF(41)（10⁻⁹M）和AVP（10⁻⁸M）可使ACTH分泌显著增加，而单独使用OT（10⁻⁸M）则无作用。然而，相同浓度的OT可显著增强ACTH对CRF(41)的反应，而对ACTH对AVP的反应无影响。这些数据支持了OT在调节ACTH分泌中具有生理作用。
