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通过注射白喉毒素使电刀鱼(Sternarchus)电细胞纤维脱髓鞘。

Demyelination of Sternarchus electrocyte fibers by injection of diphtheria toxin.

作者信息

Quick D C, Waxman S G

出版信息

J Neurol Sci. 1978 Feb;35(2-3):235-41. doi: 10.1016/0022-510x(78)90006-0.

Abstract

Diphtheria toxin was injected into the electric organ of the gymnotid fish, Sternarchus albifrons. After 10 days, there was extensive demeylination of electrocyte fibers in the area of injection. Electron microscopy showed that paranodal loops of myelin do not separately cleanly from the axon, and remnants of the myelin loops may persist after demyelination of the internodes is nearly complete. The dense cytoplasmic undercoating of the nodal axolemma may disappear before the paranodal junctions are completely gone. Observations of demyelination of internodes between the elaborate, inexcitable nodes suggest that the presence of myelin may not be necessary for the maintenance of structural differentiation of this region of the axolemma. Use of diphtheria toxin to demyelinate Sternarchus electrocytes may provide a useful system for experimental neuropathological studies.

摘要

将白喉毒素注入裸背电鳗科鱼类白线翎电鳗的发电器官。10天后,注射区域的电细胞纤维出现广泛的脱髓鞘现象。电子显微镜显示,髓鞘的结旁环不能完全干净地与轴突分离,并且在节间脱髓鞘几乎完成后,髓鞘环的残余物可能仍然存在。在结旁连接完全消失之前,结部轴膜致密的细胞质内膜可能会消失。对精细的、不可兴奋的结之间节间脱髓鞘的观察表明,髓鞘的存在对于维持该区域轴膜的结构分化可能不是必需的。使用白喉毒素使白线翎电鳗的电细胞脱髓鞘可能为实验性神经病理学研究提供一个有用的系统。

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