Cunietti E, Locatelli E, Vaiani G, Baggio E, Gandini M C, Gandini R, Fasoli A
Minerva Med. 1984 Apr 28;75(18):1041-6.
Perchloric acid soluble proteins (PPS) and their content of N-acetylneuraminic acid (NANA) may serve as valuable tumor markers for a variety of malignant neoplasms. To evaluate their clinical significance, PPS, NANA and carcino-embryonic antigen (CEA) were measured in 32 patients with lung cancer. High PPS (greater than or equal to 0,73 mg/ml) and NANA (greater than or equal to 96 micrograms/ml) levels occurred in 8 of 50 (16%) healthy volunteers and respectively in 22% and 54% of patients. CEA levels were high (greater than or equal to 3 ng/ml) in 1 out of 21 (5%) healthy volunteers and in 83% of the patients; 84% of the patients showed an elevation of NANA and of CEA. The highest values of the three markers seem to be associated with extensive disease but no statistically significant difference has emerged from the comparison of patients with limited disease with the ones with extensive involvement. Changes of the tumor mass correlate with changes of serum levels of PPS, NANA and CEA. It is concluded that CEA determination is clinically valuable in lung cancer, while PPS and NANA do not provide greater information.
高氯酸可溶性蛋白（PPS）及其N - 乙酰神经氨酸（NANA）含量可能是多种恶性肿瘤有价值的肿瘤标志物。为评估其临床意义，对32例肺癌患者测定了PPS、NANA和癌胚抗原（CEA）。50名健康志愿者中有8名（16%）PPS水平高（大于或等于0.73mg/ml），NANA水平高（大于或等于96μg/ml）的分别占22%和54%。21名健康志愿者中有1名（5%）CEA水平高（大于或等于3ng/ml），患者中则为83%；84%的患者NANA和CEA升高。三种标志物的最高值似乎与广泛病变有关，但局限期患者与广泛受累患者比较未发现统计学显著差异。肿瘤肿块的变化与血清PPS、NANA和CEA水平的变化相关。结论是，CEA测定在肺癌临床中有价值，而PPS和NANA未提供更多信息。
