• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Potentiation of the antitumor action of 5-fluorouracil with 5-ethyl-2'-deoxyuridine in human colorectal tumor xenografts.

作者信息

Kopper L, Magyarosy E, Jeney A, Lapis K, Szabolcs A, Otvös L

出版信息

Oncology. 1984;41(3):155-8. doi: 10.1159/000225813.

DOI:10.1159/000225813
PMID:6328393
Abstract

The tumor growth inhibitory effect of 5-ethyl-2'-deoxyuridine ( EUdR ) in combination with 5-fluorouracil (5-FU) has been studied on four human colorectal xenograft lines. In all lines the EUdR pretreatment potentiated the effect of 5-FU presumably due to the increased incorporation of 5-FU into RNA via elevated intracellular thymidine concentration and decreased rate of 5-FU catabolism.

摘要

相似文献

1
Potentiation of the antitumor action of 5-fluorouracil with 5-ethyl-2'-deoxyuridine in human colorectal tumor xenografts.
Oncology. 1984;41(3):155-8. doi: 10.1159/000225813.
2
[Potentiation of 5-fluorouracil efficacy. Molecular mechanisms playing a role in the cytotoxic action of 5-fluorouracil and 5-ethyl-2'-deoxyuridine (EUdR) combination].[5-氟尿嘧啶疗效的增强。5-氟尿嘧啶与5-乙基-2'-脱氧尿苷（EUdR）联合用药细胞毒性作用中的分子机制]
Magy Onkol. 2004;48(3):243-51. Epub 2004 Nov 1.
3
5-Ethoxy-2'-deoxyuridine, a novel substrate for thymidine phosphorylase, potentiates the antitumor activity of 5-fluorouracil when used in combination with interferon, an inducer of thymidine phosphorylase expression.5-乙氧基-2'-脱氧尿苷是胸苷磷酸化酶的一种新型底物，当与胸苷磷酸化酶表达诱导剂干扰素联合使用时，可增强5-氟尿嘧啶的抗肿瘤活性。
Cancer Res. 1995 Aug 15;55(16):3543-50.
4
Selective modulation of 5-fluorouracil action in patients with colorectal carcinoma.
Chemioterapia. 1985 Oct;4(5):377-82.
5
Levamisole plus 5-fluorouracil inhibits the growth of human colorectal xenografts in nude mice.
Eur J Cancer. 1992;28A(6-7):1137-9. doi: 10.1016/0959-8049(92)90473-f.
6
5-ethyl-2'-deoxyuridine, a modulator of both antitumour action and pharmacokinetics of 5-fluorouracil.5-乙基-2'-脱氧尿苷，一种5-氟尿嘧啶抗肿瘤作用和药代动力学的调节剂。
J Cancer Res Clin Oncol. 1999 Dec;125(12):675-84. doi: 10.1007/s004320050333.
7
Preliminary evidence that incorporation of 5-fluorouracil into RNA correlates with antitumor response.
Cancer Invest. 1992;10(4):265-9. doi: 10.3109/07357909209032750.
8
Enhanced antitumor activity of 5-fluorouracil in combination with 2'-deoxyinosine in human colorectal cell lines and human colon tumor xenografts.5-氟尿嘧啶与2'-脱氧肌苷联合应用对人结肠癌细胞系和人结肠癌异种移植瘤的抗肿瘤活性增强。
Clin Cancer Res. 2000 Apr;6(4):1529-35.
9
Evaluation of irinotecan in combination with 5-fluorouracil or etoposide in xenograft models of colon adenocarcinoma and rhabdomyosarcoma.伊立替康联合5-氟尿嘧啶或依托泊苷在结肠腺癌和横纹肌肉瘤异种移植模型中的评估。
Clin Cancer Res. 1996 Jan;2(1):107-18.
10
Recombinant human interferon alpha-2a increases 5-fluorouracil efficacy by elevating fluorouridine concentration in tumor tissue.
Anticancer Res. 1994 May-Jun;14(3A):1155-9.