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使用抗前列腺酸性磷酸酶的放射性标记抗体进行前列腺癌成像的临床研究。

Clinical studies of prostatic cancer imaging with radiolabeled antibodies against prostatic acid phosphatase.

作者信息

Goldenberg D M, DeLand F H

出版信息

Urol Clin North Am. 1984 May;11(2):277-81.

PMID:6328719
Abstract

Conventional antibodies against prostatic acid phosphatase, labeled with iodine-131, have been administered to patients with prostatic carcinoma for the external scintigraphic imaging of tumors containing prostatic acid phosphatase (radioimmunodetection). The method has been found to be safe and reliable for imaging of primary tumors and non-bone metastases, even differentiating between lung tumors of prostatic and pulmonary origin.

摘要

已将用碘 - 131标记的抗前列腺酸性磷酸酶的传统抗体给予前列腺癌患者,用于对含有前列腺酸性磷酸酶的肿瘤进行体外闪烁成像(放射免疫检测)。已发现该方法对于原发性肿瘤和非骨转移灶的成像安全可靠,甚至能够区分前列腺来源和肺来源的肺部肿瘤。

相似文献

1
Clinical studies of prostatic cancer imaging with radiolabeled antibodies against prostatic acid phosphatase.使用抗前列腺酸性磷酸酶的放射性标记抗体进行前列腺癌成像的临床研究。
Urol Clin North Am. 1984 May;11(2):277-81.
2
Radioimaging of the prostate and metastases of prostatic carcinoma with 99mTc-labelled prostatic acid phosphatase-specific antibodies and their Fab fragments.用99mTc标记的前列腺酸性磷酸酶特异性抗体及其Fab片段对前列腺和前列腺癌转移灶进行放射性成像。
Ann Clin Res. 1984;16(1):51-2.
3
Radioimmunodetection of prostatic cancer. In vivo use of radioactive antibodies against prostatic acid phosphatase for diagnosis and detection of prostatic cancer by nuclear imaging.
JAMA. 1983 Aug 5;250(5):630-5. doi: 10.1001/jama.250.5.630.
4
Metastatic prostatic pulmonary nodules with normal bone image.骨影像正常的转移性前列腺肺结节
J Nucl Med. 1983 Nov;24(11):1026-7.
5
Misleading renal stasis on bone scintigraphy in diffuse symmetrical skeletal metastases of prostatic carcinoma.前列腺癌弥漫性对称性骨转移时骨闪烁显像中出现的误导性肾淤积
Rofo. 1987 Oct;147(4):465-6. doi: 10.1055/s-2008-1048682.
6
Detection of tumours using radiolabelled antibodies.使用放射性标记抗体检测肿瘤。
Radiography. 1983 Jan;49(577):5-12.
7
Radioimmunodetection of lymph node invasion in prostatic cancer. The use of iodine 123 (123I)-labeled monoclonal anti-prostatic acid phosphatase (PAP) 227 A F(ab')2 antibody fragments in vivo.前列腺癌淋巴结转移的放射免疫检测。体内使用碘123(¹²³I)标记的单克隆抗前列腺酸性磷酸酶(PAP)227 A F(ab')₂抗体片段。
Cancer. 1989 Jul 1;64(1):1-5. doi: 10.1002/1097-0142(19890701)64:1<1::aid-cncr2820640102>3.0.co;2-2.
8
Colloid scintigraphy showing red bone marrow extension in patients with prostatic carcinoma.胶体闪烁显像显示前列腺癌患者红骨髓扩展。
Acta Radiol. 1992 Mar;33(2):97-102.
9
Extensive bone metastases in a patient with prostatic adenocarcinoma and normal serum prostate-specific antigen and prostatic acid phosphatase.一名前列腺腺癌患者出现广泛骨转移,但其血清前列腺特异性抗原和前列腺酸性磷酸酶水平正常。
Clin Nucl Med. 2001 Nov;26(11):962. doi: 10.1097/00003072-200111000-00025.
10
[Value of prostatic acid phosphatase and its relation to bone gammagraphy in the diagnosis of cancer of the prostate].[前列腺酸性磷酸酶的价值及其在前列腺癌诊断中与骨闪烁造影的关系]
Rev Clin Esp. 1983 Oct 15;171(1):47-50.

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